Clinical vignette: Small muscle wasting?

Clinical Vignette Session A: Vignette Award Finalists

CASE: A 50-year-old female with chronic obstructive pulmonary disease, tobacco use and bipolar disorder presented with acute, intense substernal chest pain and heart rate of 170 bpm. She had no previous cardiac history and no similar episodes in the past. She started taking lithium 2 months earlier for bipolar disorder. Her electrocardiogram showed inferior ST depression and an incomplete left ...

True Digital Artery Aneurysm - A Clinical Vignette

Swellings of the hand are commonly seen in routine clinical practuce. Ninety five percent of them are benign and most common diagnoses include ganglions, epidermoid inclusion cysts, and giant cell tumours of the tendon sheath. It is very uncommon to find true digital aneuryms in the hand. In this clinical vignette I present a case of true digital artery aneurysm, with the tell tale clinical fea...

Clinical perspective for wasting in diaphragm, an ever‐trained muscle

Dear Editor, We read with great interest the recent article comparing the mechanisms under muscle wasting in quadriceps and diaphragm using an animal model by Mangner et al. While muscle wasting in heart failure (HF) patients is associated with poor exercise capacity and prognosis, current clinical evidences in therapeutic approach have been limited to ones by exercise training. As the author r...

Muscle Wasting and IL - 6

Muscle wasting is a common feature of systemic inflammation and malignant diseases. The primary cause is accelerated proteolysis. Protein degradation was found to be accelerated by IL-6 with activation of intracellular proteases in C2C12 myotubes. IL-6 transgenic mice displayed extensive muscle wasting together with an increase of proteolytic pathways. The increase in activities and mRNA levels...

2014 Clinical Vignette and Research Competition